Hailey-Hailey Disease: A Case Study Report with Review of Literature |
Author : Dr. Shweta , Dr. Vijetha Rai , Dr. Kuladeepa Ananda Vaidya , & Dr. Sukesh4 |
Abstract | Full Text |
Abstract :Hailey-Hailey disease (HHD), also called as familial benign chronic pemphigus, is a rare
autosomal dominant blistering skin disease with waxing and waning in its clinical course. It
is characterized by the presence of flaccid vesiculo-pustules, crusted erosions or expanding
plaques in the areas of friction such as neck, axilla, groins, and perineum. Histopathologically
shows suprabasal separations, inconspicuous dyskeratosis, acantholytic cells within the
epidermis, giving a dilapidated brick wall appearance. Here we have discussed about the
clinical and histopathological features of HHD and various differential diagnosis for this disease |
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Subacute Sclerosing Panencephalitis (SSPE) in a 10 ½ Year Old Male Child |
Author : Edwin Dias |
Abstract | Full Text |
Abstract :Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of
childhood and early adolescence, caused by persistent defective measles virus. A 10 ½ yearold male child with h/o having normal milestones till the age of 15 months had an episode of
measles for which child was hospitalized. After one year he showed gradual deterioration of
already attained milestones but continued regression of milestones noticed, presented to the
department at 10½ years with h/o not getting up from the bed. Patients usually have
behavioural changes, myoclonus, dementia, visual disturbances, and pyramidal and
extrapyramidal signs and can cause death within 1-3 years of presentations. The diagnosis is
based upon characteristic clinical manifestations, the presence of characteristic periodic EEG
discharges, and demonstration of raised antibody titre against measles in the plasma and
cerebrospinal fluid. Treatment for SSPE is being researched. A combination of oral
Isoprinosine and intraventricular interferon alfa appears to be the best effective treatment.
Patients responding to treatment need to receive it lifelong. At present effective measles
vaccination is the only solution to SSPE. |
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Users Perspectives on Online Pharmacy Model |
Author : Architha Aithal1 & Dr. A. R. Shabaraya2 |
Abstract | Full Text |
Abstract :The advents in technology through continuous innovations have supported to improve the
quality of the human life in the society. One of the innovation due to the invention of ICT
based online/mobile high-speed internet is e-business which allowed the development of
online shopping/purchase of both intangible and tangible commodities online. The major
advantage and benefit of this online model is its ubiquity, convenience, and low cost to the
customer. The online shopping/purchase model is now becoming popular especially among
youngsters. One variation of this e-purchase model is online pharmacy model where a
consumer can purchase the prescribed drug online to take some of the advantages of this
model. In this paper, we have studied the customer’s attitude, views, and concern on this new
channel of drug distribution using the data collected by online questionnaire from the general
population. The data obtained from this survey is analysed, assessed and interpreted. Based
on information collected and focused group study, the online pharmacy model is analysed
using ABCD analysis framework. The various issues related to online pharmacy, affecting
factors are studies under ABCD constructs using ABCD listing methodology. Based on the
outcome of the study, many recommendations are suggested for developing proper
controlling mechanism/regulations for drug control authorities of the country to avoid misuse
of the online channel for the drug purchase.
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The Concept of Ideal Drug &its Realization Opportunity using Nanopharmaceutical Research Scenario |
Author : Architha Aithal & P. S. Aithal |
Abstract | Full Text |
Abstract :New drug research is considered as a very important research area and probably found more
investments of resources and time during the last few centuries. Drug research also
contributed to the progress of medical sciences substantially and improving characteristics of
drugs in terms of various predicted properties is continued as a challenge and agenda of these
researches. Though the objective of drug research is continuous improvements of existing
drugs in terms of their curing ability and to discover new drugs which have substantial
improved abilities to cure many existing and new diseases, the final goal of drug research is
directed to identifying one drug which has the ability to cure all diseases. Such drug system
which can cure any diseases instantaneously is called ideal drug or ideal medicine. Based on
the exact property expectations from a drug system as a medicine to cure all diseases is still
unknown and a systematic study on the goal of ideal drug discovery is yet to be established.
In this paper, we have made an attempt to identify the characteristics of an ideal drug which
can cure all diseases in the universe. Further, we discussed the challenges and opportunities
to realize such an ideal drug which can cure all the diseases. We also analysed the possibility
of using nanotechnology which is emerging as universal technology to realize the possibility
of developing ideal drug in practice. The advantages, benefits, constraints, and disadvantages
of using nanotechnology in drug research with the goal of improving them towards an ideal
drug system are also listed. Finally, the comparison is made between conventional drugs and
nanotechnology based drugs in terms of Ideal System Characteristics.This paper is on
futuristic research along with new knowledge creation and analysis based new interpretation
of nanotechnology in medicinal drugs |
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The Concept of Ideal Drug &its Realization Opportunity using Nanopharmaceutical Research Scenario |
Author : Architha Aithal & P. S. Aithal |
Abstract | Full Text |
Abstract :New drug research is considered as a very important research area and probably found more
investments of resources and time during the last few centuries. Drug research also
contributed to the progress of medical sciences substantially and improving characteristics of
drugs in terms of various predicted properties is continued as a challenge and agenda of these
researches. Though the objective of drug research is continuous improvements of existing
drugs in terms of their curing ability and to discover new drugs which have substantial
improved abilities to cure many existing and new diseases, the final goal of drug research is
directed to identifying one drug which has the ability to cure all diseases. Such drug system
which can cure any diseases instantaneously is called ideal drug or ideal medicine. Based on
the exact property expectations from a drug system as a medicine to cure all diseases is still
unknown and a systematic study on the goal of ideal drug discovery is yet to be established.
In this paper, we have made an attempt to identify the characteristics of an ideal drug which
can cure all diseases in the universe. Further, we discussed the challenges and opportunities
to realize such an ideal drug which can cure all the diseases. We also analysed the possibility
of using nanotechnology which is emerging as universal technology to realize the possibility
of developing ideal drug in practice. The advantages, benefits, constraints, and disadvantages
of using nanotechnology in drug research with the goal of improving them towards an ideal
drug system are also listed. Finally, the comparison is made between conventional drugs and
nanotechnology based drugs in terms of Ideal System Characteristics.This paper is on
futuristic research along with new knowledge creation and analysis based new interpretation
of nanotechnology in medicinal drugs |
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Diagnostic Spirometry in Pediatric Population |
Author : Chris Sarah Mathew & Dr. Edwin Dias |
Abstract | Full Text |
Abstract :Pediatric respiratory diseases are accountable for significant mortality and morbidity in
smaller age groups. Out of the various pulmonary functions tests available, spirometry is
considered to as an easier and useful tool in the diagnosis and monitoring of various pediatric
respiratory diseases. This conceptual review on spirometry briefs the utility of spirometry in
the pediatric population and the importance of addressing it’s under-utility in the medical fraternity. |
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Validated Spectroscopic Methods for the Determination of Fluoxetine HCl and Lamivudine in Bulk and Marketed Formulations |
Author : Subrahmanyam E. V. S., Kumara Prasad S. A., & Shabaraya A. R. |
Abstract | Full Text |
Abstract :A simple, convenient analytical methods were developed for the estimation of Fluoxetine
HCl (FLU) and Lamivudine (LAM) in bulk and pharmaceutical dosage forms. The method
for Fluoxetine HCl is based on the reaction between FLU and crystal violet in presence of
Chloramine T and Sulphuric Acid. The blue coloured complex obeyed the Beer-Lamberts
law in the concentration range of 0-2.5µg/ml at ?-max 603nm. The correlation coefficient
was found to be 0.9991. This method was validated for linearity, sensitivity, accuracy,
precision, LOD, LOQ and robustness.In the case of Lamivudine (LAM) the colour reaction is
based on reaction involving the formation of greenish blue complex between Lamivudine and
malachite green in the presence of Chloromine T (CT) and sulphuric acid. It obeys the BeerLamberts law in the concentration range of 0.3-2.7 µg/ml at ?-max of 623nm. The correlation
coefficient was found to be 0.9997. The method was validated for linearity, sensitivity,
accuracy, precision, LOD, LOQ and robustness |
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MRT as a Major Component of Physical Therapy Intervention for a Child with Congenital Muscular Torticollis: A Case Report |
Author : Sonali Shrivastava & K. S. Arif |
Abstract | Full Text |
Abstract :Congenital muscular torticollis (CMT) is a rare congenital musculoskeletal disorder
characterised by unilateral shortening of the sternocleidomastoid muscle. It presents in newborn infants or young children with a reported incidence ranging from 0.3% to 2%. The
Matrix concept was developed by Dr. Ulrich Randoll at the University of Erlangen Germany.
According to this concept, life is a rhythmic movement. Diseases are disturbances until total
stop. Basic therapy must be re-adaptation of rhythms on levels of cell biological regulation.
This article reports a case of a 4months old female child successfully managed by Matrix
Rhythm Therapy as a major part of physiotherapy for left side congenital muscular
torticollis.The purpose of the case report is to find the efficacy of Matrix Rhythm Therapy on
the neck movement and head alignment of a child with left side congenital muscular
torticollis. Intervention included MRT,AROM, assisted movements in the neck region.
Changes in the amounts of lateral head till were documented using still photography. The
result of the study showed that child assumed a midline head posture in sitting position by the
fifth session of therapeutic intervention (nine days). |
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Metabolic Syndrome with Oppositional Defiant Disorder in an 11 Year Old Girl |
Author : Dr. Edwin Dias |
Abstract | Full Text |
Abstract :Metabolic Syndrome in adolescent in India is of recent origin due to the better socioeconomic
conditions and the growing obesity epidemic. An 11 year old female child presented with
features of Metabolic Syndrome and Oppositional Defiant Disorder. Child was treated with
antihypertensive medication and put on dietary and exercise regimen. Child was given
counselling for the Oppositional Defiant Disorder after being evaluated by Psychiatrist. |
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A Case Report of 2.5 Years Old, Male Child with Megalencephaly with Mental Retardation, Seizure Disorder, and GERD |
Author : Edwin Dias |
Abstract | Full Text |
Abstract :A child of 2.5 years old had an intractable seizure, clinically had megalencephaly and mental
retardation. On evaluation, video EEG showed fronto-central seizures and dysfunction R 1,
scalp EEG showed bilateral paroxysmal bursts, MRI brain showed prominent vascular spaces
in the hemisphere, GE reflux scan showed GERD. Other investigations were within normal
limits. The child was treated with antiepileptics and antireflux measures and also rehabilitation. |
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Dysphonia Plica Ventricularis and Emotional Dysregulation |
Author : Dr. Edwin Dias , Dr. Mithun S.*, & Gouri Lingaraddi |
Abstract | Full Text |
Abstract :Dysphonia plica ventricularis(DPV) is a type of functional dysphonia(FD) which can be
caused by several reasons. DPV-emotional type is seen secondary to emotional crisis which is
equivalent to psychogenic/dissociative dysphonia. Here we describe a case of DPV secondary
to emotional dysregulation with an underlying emotionally unstable personality disorder.
Crisis intervention and emphasis on regular compliance to treatment has been discussed. |
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Anatomical Pathophysiological and Pathogenesis of UTI |
Author : Edwin Dias |
Abstract | Full Text |
Abstract :UTI is initiated and caused by a number of factors, an understanding of the causation helps to
Diagnose and treat it adequately. Organisms and host factors responsible for the occurrence
and pathogenesis, are crucial in the diagnosis and treatment to prevent serious sequelae. Ecoli is a main organism causing UTI |
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Dissociative Dysphonia in Delusional Disorder |
Author : Dr. Mithun S. , & Dr. Hanock Nischal |
Abstract | Full Text |
Abstract :Dissociative dysphonia is less commonly seen in general population. Previous literature has
focussed on interplay of dysphonia mainly in schizophrenia or schizoaffective disorders. Here
we discuss a unique case of delusional disorder with dissociative dysphonia. The challenges
in the evaluation and management are discussed. |
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